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Zotatifin is a first-in-class, sequentially selective inhibitor of RNA helicase eIF4A1.
| Molecular Weight | 487.55 |
| Formula | C28H29N3O5 |
| CAS Number | 2098191-53-6 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage | 2-8°C |
[5] Mehdi Bouhaddou, et al. Cell. The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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| 4EGI-1
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. |
| SBI-0640756
SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. |
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| GCN2-IN-1
GCN2-IN-1 (A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC50 of <0.3 μM in the enzyme assay and an IC50 of 0.3-3 μM in the cell assay. |
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