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ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active.
| Molecular Weight | 502.53 |
| Formula | C23H17F3N4O2S2 |
| CAS Number | 2031177-48-5 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related NEDD8-activating Enzyme Products |
|---|
| Pevonedistat
Pevonedistat (MLN4924) is a first-of-its-kind (first-in-class) small molecule inhibitor of Nedd8 activating enzyme (NAE) with an IC50 of 4.7 nM. |
| TAS4464
TAS4464 is a highly selective inhibitor of NEDD8 activated enzyme (NAE),IC50 The value is 0.955 nM. |
| NAE-IN-M22
NAE-IN-M22 is a potent, selective, and reversible inhibitor of NEDD8-activating enzyme (NAE) in the micromolar range. In addition, NAE-IN-M22 inhibits the growth of various cancer cells and induces apoptosis in A549 cells. |
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