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ZM 306416 is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM.
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Source | J Biomol Screen (2012). Figure 6. ZM 306416 |
| Method | Assessment of the anti-proliferative effects of hits against a panel of established cell lines | |
| Cell Lines | EGFR cell lines A549 and H2030 | |
| Concentrations | 10 μM | |
| Incubation Time | - | |
| Results | Confirming the newly identified inhibitory activity of ZM-306416 toward EGFR, this compound induced selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011, while sparing the wild type EGFR cell lines A549 and H2030. |
| Molecular Weight | 333.74 |
| Formula | C16H13ClFN3O2 |
| CAS Number | 690206-97-4 |
| Solubility (25°C) | DMSO 47 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related VEGFR/PDGFR Products |
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| Tivozanib (AV-951)
Tivozanib (AV-951) is a potent VEGFR-1, 2 and 3, c-Kit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM respectively. |
| Axitinib
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| Regorafenib
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