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ZLN005 is a novel transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). ZLN005 stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM. ZLN005 increased PGC-1α and downstream gene transcription in skeletal muscle, whereas hepatic PGC-1α and gluconeogenesis genes were reduced. ZLN005 increased fat oxidation and improved the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice. ZLN005 selectively elevated the expression of PGC-1α in myotubes and skeletal muscle and exerted promising therapeutic effects for treating type 2 diabetes.
J Hazard Mater. 2024 Apr 16;471:134331.
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis
ZLN005 purchased from AbMole
Neuroscience. 2023 May 3;521:134-147.
Resveratrol Attenuates the Disruption of Lipid Metabolism Observed in Amyloid Precursor Protein/Presenilin 1 Mouse Brains and Cultured Primary Neurons Exposed to Aβ
ZLN005 purchased from AbMole
Toxicol Sci. 2022 Oct 21;kfac110.
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis
ZLN005 purchased from AbMole
Am J Pathol. 2020 Apr 11;S0002-9440(20)30191-7.
Silent Mating-Type Information Regulation 2 Homolog 1 Attenuates the Neurotoxicity Associated With Alzheimer Disease via a Mechanism Which May Involve Regulation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-α
ZLN005 purchased from AbMole
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Source | Diabetes (2013). Figure 1. ZLN005 |
| Method | qRT-PCR | |
| Cell Lines | HEK293 cells | |
| Concentrations | 10 μmol/L | |
| Incubation Time | 24 h | |
| Results | The mRNA levels of GLUT4, NRF1, estrogen-related receptor a (ERRa), cytochrome c oxidase 5b (cox5b), and acyl-CoA oxidase were increased by ZLN005 (10 μmol/L). |
| Molecular Weight | 250.34 |
| Formula | C17H18N2 |
| CAS Number | 49671-76-3 |
| Solubility (25°C) | DMSO 35 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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