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Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist. Ziprasidone has high affinity for rat (Ki: 3.4 nM)/human (2.5 nM) 5-HT1A receptors, 5-HT2A (0.42 nM), and dopamine D2 receptors (4.8 nM). Ziprasidone is an inhibitor of norepinephrine reuptake.
| Molecular Weight | 412.94 |
| CAS Number | 146939-27-7 |
| Solubility (25°C) | DMSO 13.5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Carla Biesdorf, et al. Physiologically-based pharmacokinetics of ziprasidone in pregnant women
[4] Adriane R Rosa, et al. Ziprasidone in the treatment of affective disorders: a review
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