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Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
J Hazard Mater. 2021 Aug 15;416:126138.
New insights into crosstalk between pyroptosis and autophagy co-induced by molybdenum and cadmium in duck renal tubular epithelial cells
Z-YVAD-FMK purchased from AbMole
2021 May 25 .
Caspase-1 Inhibitor Reduces Pyroptosis in Kidney Injury Induced by Brain Death
Z-YVAD-FMK purchased from AbMole
Environ Pollut. 2020 Oct 23;273:115919.
Inhibition of ROS/NLRP3/Caspase-1 mediated pyroptosis attenuates cadmium-induced apoptosis in duck renal tubular epithelial cells
Z-YVAD-FMK purchased from AbMole
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Source | Cell Physiol Biochem (2018). Figure 3. Z-VAD-FMK |
| Method | western blotting | |
| Cell Lines | GBM cells | |
| Concentrations | 20 μM | |
| Incubation Time | 3 h | |
| Results | To examine whether RA-induced apoptosis was caspase-dependent, we introduced the pan-caspase inhibitor z-VAD-fmk. As shown in Fig. 3D, combined treatment with z-VAD-fmk rescued RA-induced cell death. |
| Molecular Weight | 630.66 |
| Formula | C31H39FN4O9 |
| CAS Number | 210344-97-1 |
| Solubility (25°C) | DMSO: ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Caspase Products |
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| LY573636 (Tasisulam)
LY573636 is a novel anticancer agent that induces apoptosis through the intrinsic pathway and has antiangiogenic activity in preclinical models. |
| Q-VD-OPh
Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. |
| Z-DEVD-FMK
Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. |
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