All AbMole products are for research use only, cannot be used for human consumption.
Z-VAD-FMK (10 μM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 μM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells.
Free Radic Biol Med. 2026 Jan; .
IER3 Promotes Non-Small Cell Lung Cancer Malignancy by Suppressing Ferroptosis via the AKT/GSK3b/NRF2 Pathway
Z-VAD-FMK purchased from AbMole
Antioxidants (Basel). 2025 Jul 29;14(8):930.
CIRBP Stabilizes Slc7a11 mRNA to Sustain the SLC7A11/GPX4 Antioxidant Axis and Limit Ferroptosis in Doxorubicin-Induced Cardiotoxicity
Z-VAD-FMK purchased from AbMole
Mol Ther Oncol. 2025 Aug 05;33(3):201027.
Syncytial death mediated by oncolytic virus rVSV-NDV dynamically activates immunogenic apoptosis and necroptosis in human lung cancer cells
Z-VAD-FMK purchased from AbMole
J Cancer. 2025 Jan 01;16(2):417-429.
TYMS Enhances Colorectal Cell Antioxidant Capacity Via the KEAP1-NRF2 Pathway to Resist Ferroptosis
Z-VAD-FMK purchased from AbMole
Invest New Drugs. 2025 Mar 17;43(2):301-310.
Evaluation of the anti-leukemia activity and underlying mechanisms of the novel perinucleolar compartment inhibitor CTI-2 in acute myeloid leukemia
Z-VAD-FMK purchased from AbMole
STAR Protoc. 2025 Jan 20.
Protocol for generating liver metastasis microtissues to decipher cellular interactions between metastatic intestinal cancer and liver tissue
Z-VAD-FMK purchased from AbMole
ASPET Discovery. 2025 Sep 03; .
Targeting Ribonucleotide Reductase to Enhance the Antileukemic Activity of Gilteritinib Against Chemoresistant FLT3-ITD AML
Z-VAD-FMK purchased from AbMole
Cancer Res. 2024 Jan;0008-5472.
The imipridone ONC213 targets α-ketoglutarate dehydrogenase to induce mitochondrial stress and suppress oxidative phosphorylation in acute myeloid leukemia
Z-VAD-FMK purchased from AbMole
Biochem Pharmacol. 2024 Feb 17;116065.
Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax
Z-VAD-FMK purchased from AbMole
Toxicol Appl Pharmacol. 2024 Jan;116825.
Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing …
Z-VAD-FMK purchased from AbMole
Leuk Res. 2024 Jun 29;52(1):46.
Combining the novel FLT3 and MERTK dual inhibitor MRX-2843 with venetoclax results in promising antileukemic activity against FLT3-ITD AML
Z-VAD-FMK purchased from AbMole
Cancer Res. 2023 Jan 18;83(2):251-263.
MEX3A mediates p53 degradation to suppress ferroptosis and facilitate ovarian cancer tumorigenesis
Z-VAD-FMK purchased from AbMole
JACC-BASIC TRANSL SC. 2023 May 31.
PCSK9 Promotes Hypoxia-Induced Endothelial Cell Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia
Z-VAD-FMK purchased from AbMole
Food Science and Human Wellness. 2023 Jun 1.
3-epi-betulinic acid 3-O-β-D-glucopyranoside (eBAG) induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma
Z-VAD-FMK purchased from AbMole
J Cell Physiol. 2023 Jun 3.
miR-210/NF-κB axis: A new direction for regulating cadmium-induced pig artery inflammatory injury
Z-VAD-FMK purchased from AbMole
Neoplasma. 2023 Feb 23;221217N1185.
Synergistic activity and mechanism of cytarabine and MCL-1 inhibitor AZD5991 against acute myeloid leukemia
Z-VAD-FMK purchased from AbMole
J Cell Mol Med. 2022 May;26(9):2646-2657.
Venetoclax enhances DNA damage induced by XPO1 inhibitors: A novel mechanism underlying the synergistic antileukaemic effect in acute myeloid leukaemia
Z-VAD-FMK purchased from AbMole
Eur J Surg Oncol. 2022 Feb 19;S0748-7983(22)00114-7..
In desmoid-type fibromatosis cells sorafenib induces ferroptosis and apoptosis, which are enhanced by autophagy inhibition
Z-VAD-FMK purchased from AbMole
J Hazard Mater. 2021 Mar 15;406:124682.
Regulation of H 2 S-induced necroptosis and inflammation in broiler bursa of Fabricius by the miR-15b-5p/TGFBR3 axis and the involvement of oxidative stress in this process
Z-VAD-FMK purchased from AbMole
Environ Pollut. 2021 Feb 1;270:116051.
Bisphenol AF induces apoptosis via estrogen receptor beta (ERβ) and ROS-ASK1-JNK MAPK pathway in human granulosa cell line KGN
Z-VAD-FMK purchased from AbMole
Ecotoxicol Environ Saf. 2021 Sep 1;220:112341.
Cadmium induces apoptosis of human granulosa cell line KGN via mitochondrial dysfunction-mediated pathways
Z-VAD-FMK purchased from AbMole
Ecotoxicol Environ Saf. 2021 Jan 15;208:111429.
Bisphenol A induces apoptosis through GPER-dependent activation of the ROS/Ca 2+-ASK1-JNK pathway in human granulosa cell line KGN
Z-VAD-FMK purchased from AbMole
Anat Rec (Hoboken). 2020 Jan 21.
Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation
Z-VAD-FMK purchased from AbMole
| Molecular Weight | 467.49 |
| Formula | C22H30FN3O7 |
| CAS Number | 187389-52-2 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Ilangovan R, et al. J Biol Chem. Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells.
| Related Caspase Products |
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| PAC-1
PAC-1 is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). |
| MDK83190
MDK83190 (Apoptosis Activator 2) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. |
| LY573636 (Tasisulam)
LY573636 is a novel anticancer agent that induces apoptosis through the intrinsic pathway and has antiangiogenic activity in preclinical models. |
| Q-VD-OPh
Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. |
| Z-DEVD-FMK
Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. |
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