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YL-109 is a novel anticancer agent, which can inhibit breast cancer cell growth and invasiveness in vitro and in vivo, YL-109 is also an STUB1 enhancer. In addition, YL-109 repressed the sphere-forming ability and the expression of stem cell markers in MDA-MB-231 mammosphere cultures. YL-109 increased the expression of carboxyl terminus of Hsp70-interacting protein (CHIP), which suppresses tumorigenic and metastatic potential of breast cancer cells by inhibiting the oncogenic pathway. YL-109 induced CHIP transcription because of the recruitment of the aryl hydrocarbon receptor (AhR) to upstream of CHIP gene in MDA-MB-231 cells. Consistently, the antitumor effects of YL-109 were depressed by CHIP or AhR knockdown in MDA-MB-231 cells.
| Molecular Weight | 257.31 |
| Formula | C14H11NO2S |
| CAS Number | 36341-25-0 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Aryl hydrocarbon Receptor Products |
|---|
| StemRegenin 1
StemRegenin 1 is an AhR inhibitor with IC50 of 127 nM. |
| Carbidopa
Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM. |
| Diosimin
Diosimin is a flavonoid glycoside found in citrus fruits, hyssop, and rosemary. Diosimin is also an agonist of the aryl hydrocarbon receptor (AhR), capable of upregulating the expression of p53, caspase 3, and caspase 9 in A431 cells, while downregulating the levels of Bcl-2 and matrix metalloproteinases (MMP-2 and MMP-9). Its metabolite, diosmetin, inhibits 3H-dopamine uptake in a dose-dependent manner with an IC50 value of 4 μM. |
| CH-223191
CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM. *The compound is unstable in solutions, freshly prepared is recommended |
| Perillaldehyde
Perillaldehyde inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway. |
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