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Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 has the potential for the research of impairment of learning and memory associated DG dysfunction.
| Molecular Weight | 400.47 |
| Formula | C24H24N4O2 |
| CAS Number | 2097826-24-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 66.67 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light, dry, sealed |
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NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. |
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Products are for research use only. Not for human use. We do not sell to patients.
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