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Y-39983 (Y-33075) dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM, derived from Y-27632, inhibited ROCK more potently than Y-27632.
Theranostics. 2024 Sep 9;14(15):5762-5777.
ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium
Y-39983 dihydrochloride purchased from AbMole
Theranostics. 2024 Sep 09;14(15):5762-5777.
ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium
Y-39983 dihydrochloride purchased from AbMole
| Molecular Weight | 353.25 |
| Formula | C16H18Cl2N4O |
| CAS Number | 173897-44-4 |
| Solubility (25°C) | DMSO 80 mg/mL Water 40 mg/mL |
| Storage | 4°C, dry, sealed |
| Related ROCK Products |
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| Y-27632 dihydrochloride
Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. In addition, Y-27632 inhibited LPA-induced entosis. |
| Thiazovivin
Thiazovivin is a selective small molecule Rho-associated kinase (ROCK) inhibitor which significantly improves (200-fold) the efficiency of iPSC generation from human fibroblasts. |
| Fasudil hydrochloride
Fasudil hydrochloride is a potent Rho-associated kinase inhibitor with IC50 of 10.7 μM. |
| RKI-1447
RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 6 nM, respectively. |
| GSK429286A
GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively. |
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Products are for research use only. Not for human use. We do not sell to patients.
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