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Y-26763

Cat. No. M7498

All AbMole products are for research use only, cannot be used for human consumption.

Y-26763 Structure

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Quality Control & Documentation
Biological Activity

Y-26763 is a kir6 (KATP) channel opener and active metabolite of Y-27152. Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.

Chemical Information
Molecular Weight 276.29
Formula C14H16N2O4
CAS Number 127408-31-5
Solubility (25°C) 1eq. NaOH 27.63 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kennett, et al. Neuropharmacology. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated.

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Keywords: Y-26763 supplier, inhibitors, activators

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