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XMD8-92, via inhibition of BMK1 activation, significantly induces p21 expression in cells, and mediates suppression of cancer cell proliferation. XMD8-92 markedly abrogates the inhibitive effects of hydroxysafflor yellow A (HSYA) on hepatic stellate cell (HSC) activation, and blockes the HSYA-mediated MEF2C down-regulation.
| Cell Experiment | |
|---|---|
| Cell lines | A549 cell lines |
| Preparation method | Control and shBNIP3/shBNIP3L A549 sphere cells were treated with/without 4 μmol/L XMD8-92 for 36 hrs, and collected by trypsinization and centrifugation at 300 G for 5 mins. The resultant cells were washed twice with cold PBS and resuspended in 100 μL Annexin-binding buffer. |
| Concentrations | 4 μmol/L |
| Incubation time | 36 h |
| Animal Experiment | |
|---|---|
| Animal models | Nod/Scid mice bearing HeLa xenograft, C57Bl/6 mice bearing LL/2 xenograft |
| Formulation | |
| Dosages | ~50 mg/kg twice a day |
| Administration | i.p. |
| Molecular Weight | 474.55 |
| Formula | C26H30N6O3 |
| CAS Number | 1234480-50-2 |
| Solubility (25°C) | DMSO 48 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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