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XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2.
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Source | Anticancer Res (2017). Figure 2. XL019 |
| Method | fluorescence-activated cell sorting analyses | |
| Cell Lines | KBV20C cancer cells | |
| Concentrations | 5 μM | |
| Incubation Time | 24 h | |
| Results | As shown in Figure 2A, co-treatment with XL019 and vincristine increased the number of cells arrested in the G2 phase compared to that observed with single treatments with either agent. |
| Molecular Weight | 444.53 |
| Formula | C25H28N6O2 |
| CAS Number | 945755-56-6 |
| Solubility (25°C) | DMSO 15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Constantine S Tam, et al. Investigational Janus kinase inhibitors
| Related JAK Products |
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| Momelotinib (CYT387)
Momelotinib (CYT387) is a small-molecule, ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM respectively. |
| TG101348
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| WP1130
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