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XJB-5-131 

Cat. No. M30748

All AbMole products are for research use only, cannot be used for human consumption.

XJB-5-131  Structure

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Quality Control & Documentation
Biological Activity

XJB-5-131 is a mitochondria-targeted ROS and electron scavenger. XJB-5-131 is a bi-functional antioxidant that comprises a radical scavenger. XJB-5-131 is a synthetic antioxidant that targets mitochondria. XJB-5-131 is an effective ionizing irradiation protector and mitigator of cord blood mononuclear cells (CB MNCs).

Chemical Information
Molecular Weight 960.25
Formula C53H81N7O9
CAS Number 866404-31-1
Form Solid
Solubility (25°C) DMSO 125 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Zhiyin Xun, et al. J Huntingtons Dis. XJB-5-131 Is a Mild Uncoupler of Oxidative Phosphorylation

[2] Pater Wipf, et al. J Huntingtons Dis. A Double-Pronged Sword: XJB-5-131 Is a Suppressor of Somatic Instability and Toxicity in Huntington's Disease

[3] Zhi Zhao, et al. Cell Death Dis. XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia-reperfusion injury

[4] Aris A Polyzos, et al. PLoS One. XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent

[5] Aris Polyzos, et al. Hum Mol Genet. Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes

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Keywords: XJB-5-131  supplier, ROS, inhibitors, activators

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