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XIB4035

Cat. No. M8458

All AbMole products are for research use only, cannot be used for human consumption.

XIB4035 Structure

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Quality Control & Documentation
Biological Activity

XIB4035 is a reported agonist of the glial cell-line derived neurotrophic factor (GDNF) receptor GFRα1. XIB4035 induces GFRα1/RET phosphorylation in Neuro2A cells.

Chemical Information
Molecular Weight 456.45
Formula C26H31Cl2N3
CAS Number 529507-84-4
Solubility (25°C) DMSO: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yu-Lin Hsieh, et al. Distinct TrkA and Ret modulated negative and positive neuropathic behaviors in a mouse model of resiniferatoxin-induced small fiber neuropathy

[2] Ahmet Hke. Augmenting glial cell-line derived neurotrophic factor signaling to treat painful neuropathies

[3] Kristian L Hedstrom, et al. Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling

[4] Kimiko Tokugawa, et al. XIB4035, a novel nonpeptidyl small molecule agonist for GFRalpha-1

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  Catalog
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Keywords: XIB4035 supplier, inhibitors, activators

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