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XEN907 

Cat. No. M30875

All AbMole products are for research use only, cannot be used for human consumption.

XEN907  Structure

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Quality Control & Documentation
Biological Activity

XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain.

Chemical Information
Molecular Weight 351.4
Formula C21H21NO4
CAS Number 912656-34-9
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jiangtao Zhang, et al. Nat Struct Mol Biol. Structural basis for NaV1.7 inhibition by pore blockers

[2] Kuan Zhang, et al. Chem Commun (Camb). An unexpected cascade reaction of 3-hydroxyoxindoles with coumarin-3-carboxylates to construct 2,3-dihydrobenzofuran spirooxindoles

[3] Dhanarajan Arunprasath, et al. J Org Chem. Dictating the Reactivity of η3-Oxoallyl Pd-Intermediate toward 5- exo-trig Cyclization: Access to Indano-spirooxindoles

[4] Sultan Chowdhury, et al. Bioorg Med Chem Lett. Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain

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  Catalog
Abmole Inhibitor Catalog




Keywords: XEN907  supplier, Sodium Channel, inhibitors, activators

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