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Xanomeline increases neuronal excitability as a potent selective muscarinic 1 and type 4 (M1/M4) receptor agonist. Xanomeline can be used in the study of neurological disorders such as schizophrenia.
| Cell Experiment | |
|---|---|
| Cell lines | Primary cultured cortical neurons |
| Preparation method | In order to evaluate the effects of xanomeline on cell viability, four concentrations of xanomeline 1, 5, 10, and 15 μM were used. |
| Concentrations | 1, 5, 10, and 15 μM |
| Incubation time | 12 h |
| Animal Experiment | |
|---|---|
| Animal models | C57 BL/6J mice |
| Formulation | Not mentioned |
| Dosages | 1.0 mg/kg |
| Administration | i.p. injections |
| Molecular Weight | 281.42 |
| Formula | C14H23N3OS |
| CAS Number | 131986-45-3 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Aaron M Bender, et al. ACS Chem Neurosci. Classics in Chemical Neuroscience: Xanomeline
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