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WRW4 is a selective antagonist of formyl peptide receptor 1 (FPR1) signaling, it inhibits WKYMVm binding to FPR1 (IC50 = 0.23 μM). WRW4 inhibits Abeta42 peptide-induced superoxide generation and chemotactic migration of neutrophils, and also completely inhibits the internalization of Abeta42 peptide in human macrophages.
| Molecular Weight | 1104.27 |
| Formula | C61H65N15O6 |
| CAS Number | 878557-55-2 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Related FPR Products |
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| TC-FPR 43
TC-FPR 43 is a potent FPR2 agonist. |
| PBP10 TFA salt
PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects. |
| ACT-389949
ACT-389949 is a first-in-class, potent, selective formyl peptide receptor 2/lipoprotein A4 receptor (FPR2)/(ALX) agonist with an EC50 value of 3 nM for FPR2/ALX entry into monocytes.Additionally, ACT-389949 is an excellent tool compound for in vitro and in vivo to further analyze FPR2-regulated activity, which could be used in the development of next-generation FPR signaling-regulated anti-inflammatory therapies. |
| WKYMVM TFA
WKYMVM TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist. |
| N-Formyl-Met-Leu-Phe
N-Formyl-Met-Leu-Phe (fMLP) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR), which can inhibit TNF-alpha secretion. |
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