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WRG-28 

Cat. No. M29014

All AbMole products are for research use only, cannot be used for human consumption.

WRG-28  Structure
Size Price Availability Quantity
5mg USD 105 In stock
10mg USD 170 In stock
25mg USD 330 In stock
50mg USD 520 In stock
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Biological Activity

WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC50 of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice.

Chemical Information
Molecular Weight 410.44
Formula C21H18N2O5S
CAS Number 1913291-02-7
Form Solid
Solubility (25°C) DMSO 15.62 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yun-Sen Zhu, et al. J Orthop Surg Res. Discoidin domain receptor 2 activation of p38 mitogen-activated protein kinase as an important pathway for osteonectin-regulating osteoblast mineralization

[2] Allen Sam Titus, et al. Am J Physiol Heart Circ Physiol. Coordinated regulation of cell survival and cell cycle pathways by DDR2-dependent SRF transcription factor in cardiac fibroblasts

[3] Whitney R Grither, et al. Proc Natl Acad Sci U S A. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain

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  Catalog
Abmole Inhibitor Catalog




Keywords: WRG-28  supplier, Discoidin Domain Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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