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WR 1065

Cat. No. M7491

All AbMole products are for research use only, cannot be used for human consumption.

WR 1065 Structure

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Quality Control & Documentation
Biological Activity

WR 1065 is a cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Also exhibits broad spectrum antiviral activity in vitro.

Chemical Information
Molecular Weight 207.16
Formula C5H14N2S.2HCl
CAS Number 14653-77-1
Solubility (25°C) Water 20.72 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Bowman, et al. Br J Cancer. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.

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Keywords: WR 1065 supplier, inhibitors, activators

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