Free shipping on all orders over $ 500

WM-3835

Cat. No. M11175

All AbMole products are for research use only, cannot be used for human consumption.

WM-3835  Structure
Synonym:

WM3835

Size Price Availability Quantity
10mM*1mL in DMSO USD 79 In stock
1mg USD 32 In stock
5mg USD 72 In stock
10mg USD 123 In stock
25mg USD 244 In stock
50mg USD 369 In stock
100mg USD 595 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

WM-3835 is a potent, highly specific HBO1 (KAT7 or MYST2) inhibitor that binds directly to the acetyl-Coenzyme A binding site of HBO1 33 and WM-3835 activates apoptosis while inhibiting proliferation, migration, and invasion of osteosarcoma (OS) cells.

WM-3835 (10 mg/kg/day; ip; for21 days) potently inhibits pOS-1 xenograft growth in SCID mice.

Chemical Information
Molecular Weight 400.42
Formula C20H17FN2O4S
CAS Number 2229025-70-9
Solubility (25°C) DMSO ≥ 120 mg/mL
Storage 4°C, protect from light, sealed
References

[1] Teng-Fei Chen, et al. Int J Biol Sci. HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth

[2] Jingtian Su, et al. Pharmacol Res. The role of MOZ/KAT6A in hematological malignancies and advances in MOZ/KAT6A inhibitors

[3] Yan-Yang Gao, et al. Theranostics. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma

Related Histone Acetyltransferase Products
Curcumin

Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification.

C646

C646 is a selective inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. C646 preferentially selective for p300 versus other acetyltransferases.

MG149

MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM). MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG 149 can induce mitochondrial depolarization and promote PINK1 dependent mitochondrial clearance.

Remodelin

Remodelin is a novel, potent Acetyl-transferase NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization.

Histone Acetyltransferase Inhibitor II

Histone Acetyltransferase Inhibitor II, insulin producing cells capable of secreting blood glucose regulating hormones, specially insulin, in response to physiological signals, method of production of said cells and uses thereof.

  Catalog
Abmole Inhibitor Catalog




Keywords: WM-3835 , WM3835 supplier, Histone Acetyltransferase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.