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Wedelolactone

Cat. No. M4574

All AbMole products are for research use only, cannot be used for human consumption.

Wedelolactone Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
1mg USD 30 In stock
5mg USD 68 In stock
10mg USD 118 In stock
20mg USD 168 In stock
50mg USD 348 In stock
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Quality Control & Documentation
Biological Activity

Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11.

Chemical Information
Molecular Weight 314.04
Formula C16H10O7
CAS Number 524-12-9
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Guangju Wang, et al. Wedelolactone protects against cisplatin-induced nephrotoxicity in mice via inhibition of organic cation transporter 2

[2] Rong Fan, et al. Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis

[3] Hao Pan, et al. Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis

[4] Mao-Mao Zhu, et al. Wedelolactone alleviates doxorubicin-induced inflammation and oxidative stress damage of podocytes by IκK/IκB/NF-κB pathway

[5] Min Cheng, et al. Wedelolactone suppresses IL-1β maturation and neutrophil infiltration in Aspergillus fumigatus keratitis

[6] Nai-Jun Miao, et al. Acta Pharmacol Sin . Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1

[7] M Kobori, et al. Cell Death Differ. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex

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  Catalog
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Keywords: Wedelolactone supplier, Caspase, inhibitors, activators

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