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WAY-100135 dihydrochloride

Cat. No. M8856

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WAY-100135 dihydrochloride Structure

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Quality Control & Documentation
Biological Activity

WAY-100135 dihydrochloride is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). It is selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM).

Chemical Information
Molecular Weight 468.46
Formula C24H33N3O2 · 2HCl
CAS Number 149055-79-8
Solubility (25°C) Water: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] E A Del Bel, et al. Role of nitric oxide on motor behavior

[2] W Lscher, et al. Effects of the novel 5-HT1A receptor antagonist, (+)-WAY 100135, on stereotyped behaviour induced by the NMDA receptor antagonist dizocilpine in rats

[3] R J Rodgers, et al. Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test

[4] C Routledge, et al. Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190

[5] M Carli, et al. (S)-WAY 100135, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine

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Keywords: WAY-100135 dihydrochloride supplier, 5-HT Receptor, inhibitors, activators

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