Free shipping on all orders over $ 500

SPR719

Cat. No. M28299

All AbMole products are for research use only, cannot be used for human consumption.

SPR719 Structure
Synonym:

VXc-486

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

SPR719 (VXc-486) is a gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively.

Chemical Information
Molecular Weight 428.46
Formula C21H25FN6O3
CAS Number 1384984-18-2
Form Solid
Solubility (25°C) DMSO 20 mg/mL (ultrasonic and adjust pH to 2 with HCl)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wassihun Wedajo Aragaw, et al. Microbiol Spectr. In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus

[2] Sacha J Pidot, et al. PLoS Negl Trop Dis. In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera

[3] Dereje Abate Negatu, et al. Antimicrob Agents Chemother. Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus

[4] Lian J Pennings, et al. Antimicrob Agents Chemother. The Benzimidazole SPR719 Shows Promising Concentration-Dependent Activity and Synergy against Nontuberculous Mycobacteria

[5] Barbara A Brown-Elliott, et al. Antimicrob Agents Chemother. In Vitro Susceptibility Testing of a Novel Benzimidazole, SPR719, against Nontuberculous Mycobacteria

Related Topoisomerase Products
Amonafide

Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer.
Idarubicin

Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells.
Dexrazoxane hydrochloride

Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity.
Irinotecan Hydrochloride Trihydrate

Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I.
Topotecan hydrochloride

Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
  Catalog
Abmole Inhibitor Catalog




Keywords: SPR719, VXc-486 supplier, Topoisomerase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.