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VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV.
| Molecular Weight | 447.84 |
| CAS Number | 1052515-91-9 |
| Solubility (25°C) | DMSO 150 mg/mL |
| Storage | 2-8°C, dry, sealed |
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