Free shipping on all orders over $ 500

VU0071063

Cat. No. M8454

All AbMole products are for research use only, cannot be used for human consumption.

VU0071063 Structure

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

VU0071063 is a potent activator of Kir6.2/SUR1 KATP channels (EC50 = 10.3 μM). VU0071063 reversibly inhibits glucose-stimulated calcium influx in mouse β-islet cells. The compound VU0071063 has no affect on Kir6.2/SUR2A channels.

Chemical Information
Molecular Weight 326.39
Formula C18H22N4O2
CAS Number 333415-38-6
Solubility (25°C) DMSO: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Fabien Caill, et al. Radiolabeling and brain penetration of [ 11 C]VU0071063, a ligand of type 1 sulfonylurea receptors for positron emission tomography imaging

[2] Jelena Sikimic, et al. Possible New Strategies for the Treatment of Congenital Hyperinsulinism

[3] Sujay V Kharade, et al. Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063

[4] Zhilin Li, et al. Inward rectifier potassium (Kir) channels mediate salivary gland function and blood feeding in the lone star tick, Amblyomma americanum

[5] Rene Raphemot, et al. Direct activation of β-cell KATP channels with a novel xanthine derivative

Related Products
Poly-L-lysine (MW 150000~300000)

Poly-L-lysine

N-Phenylacrylamide

N-Phenylacrylamide

Silver diethyldithiocarbamate

Silver diethyldithiocarbamate is used in conjunction with Fe2+ to detect NO in brain, kidney, liver, and other tissues.

Methylmalonic acid

Methylmalonic acid can be used as a substrate in esterification reactions by various catalysts.

Sarcosine

Sarcosine is a glycine transporter type 1 (GlyT) inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site.

  Catalog
Abmole Inhibitor Catalog




Keywords: VU0071063 supplier, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.