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VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer.
| Molecular Weight | 420.43 |
| Formula | C25H19F3N2O |
| CAS Number | 2417718-25-1 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related YAP Products |
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| Verteporfin (CL 318952)
Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin (CL 318952) is a YAP inhibitor that disrupts YAP-TEAD interactions, and it is also an inhibitor of autophagy. |
| YAP-TEAD-IN-1 TFA
YAP-TEAD-IN-1 TFA is a competitive inhibitor of YAP-TEAD interaction with IC50 of 25 nM. |
| Super-TDU
Super-TDU is a specific YAP antagonist that targets YAP-TEAD interactions. Super-TDU can inhibit tumor growth in mouse models of gastric cancer. |
| TED-347
TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. |
| YAP/TAZ inhibitor-1
YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor with an IC50 of <0.100 μΜ in firefly luciferase assay. |
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