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VPC 23019 is a sphingosine-1-phosphate receptor antagonist. VPC 23019 inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).
| Molecular Weight | 372.4 |
| Formula | C17H29N2O5P |
| CAS Number | 449173-19-7 |
| Solubility (25°C) | 2eq. NaOH 18.62 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Regoli, et al. Eur J Pharmacol. Bradykinin receptors and their antagonists.
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| BAF312
BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. |
| SEW2871
SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. |
| CYM-5442
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