All AbMole products are for research use only, cannot be used for human consumption.
Voreloxin is an anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, causing double-strand breaks in DNA, irreversible G2 arrest, and rapid onset of apoptosis.Vosaroxin has shown efficacy as a novel cytotoxic agent, and despite a similar mechanism of action has significant advantages over anthracyclines. It evades common resistance pathways of p53 and P-glycoprotein (P- gp) and does not appear to generate significant reactive oxygen species (ROS) associated with these agents.
| Cell Experiment | |
|---|---|
| Cell lines | P388 leukemia cells |
| Preparation method | Putting cells into wells of a 96-well microtiter plate in the amount of 0.1 mL/well, preincubating for 24 h except for P388 cells, and incubating with various concentrations of a test compound in the 5% CO2 incubator at 37 °Cfor 72 h. After the culturing, 0.02 mL of a MTT solution (5 mg/mL) is put in each well, and culturing the cells for a further 4 h. The medium is removed by suction, and 0.2 mL of DMSO is put in each well to dissolve the formed formazan. Measureing the absorbance by Multiskan Bichromatic. Defining the IC50 as the drug concentration needed to produce a 50% reduction of absorbance relative to the control. |
| Concentrations | ~10 μg/mL |
| Incubation time | 72 hours |
| Animal Experiment | |
|---|---|
| Animal models | Mice implanted with P388 leukemia cells. |
| Formulation | Suspended in 0.4% CMC (carboxymethyl cellulose) |
| Dosages | ~50 mg/kg |
| Administration | i.p. |
| Molecular Weight | 401.44 |
| Formula | C18H19N5O4S |
| CAS Number | 175414-77-4 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Abbas JA, et al. Expert Opin Investig Drugs. Vosaroxin : a novel antineoplastic quinolone.
| Related Topoisomerase Products |
|---|
| Amonafide
Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer. |
| Idarubicin
Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
| Dexrazoxane hydrochloride
Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. |
| Irinotecan Hydrochloride Trihydrate
Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I. |
| Topotecan hydrochloride
Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
