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Vopratelimab

Cat. No. M24884

All AbMole products are for research use only, cannot be used for human consumption.

Vopratelimab Structure
Synonym:

JTX 2011

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Quality Control & Documentation
Biological Activity

Vopratelimab (JTX-2011) is a humanized immunoglobulin G1-kappa agonist monoclonal antibody that pecifically binds to the Inducible CO-Stimulator of T cells (ICOS). Vopratelimab retains species cross-reactivity with affinities of 0.93 nM to hICOS, 0.46 nM to cynomolgus ICOS, 3.7 nM to rat ICOS, and 0.64 nM to mICOS. Vopratelimab has antitumor immune response.

Chemical Information
CAS Number 2039148-04-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Jerry C Lee, et al. Clin Cancer Res. Agonizing over the Stimulatory Immune Checkpoint ICOS

[2] Timothy A Yap, et al. Clin Cancer Res. First-in-Human Phase I/II ICONIC Trial of the ICOS Agonist Vopratelimab Alone and with Nivolumab: ICOS-High CD4 T-Cell Populations and Predictors of Response

[3] Amanda Hanson, et al. PLoS One. ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models

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Keywords: Vopratelimab, JTX 2011 supplier, inhibitors, activators

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