Free shipping on all orders over $ 500

Voacangine 

Cat. No. M30211

All AbMole products are for research use only, cannot be used for human consumption.

Voacangine  Structure
Size Price Availability Quantity
5mg USD 880 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC50=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC50=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50=9 μM) and it shows noncompetitive inhibition against icilin (IC50=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana.

Chemical Information
Molecular Weight 368.47
Formula C22H28N2O3
CAS Number 510-22-5
Form Solid
Storage 4°C, protect from light
References

[1] Laura Milena Monsalve-Escudero, et al. Plants (Basel). The Antiviral and Virucidal Activities of Voacangine and Structural Analogs Extracted from Tabernaemontana cymosa Depend on the Dengue Virus Strain

[2] Feng Xiao, et al. J BUON. Anticancer activity of Voacangine against human oral cancer cells is due to G2/M cell cycle arrest, ROS-mediated cell death and inhibition of PI3K/AKT signalling pathway

[3] Yonghyo Kim, et al. Biomolecules. Identification and Validation of VEGFR2 Kinase as a Target of Voacangine by a Systematic Combination of DARTS and MSI

[4] Christina E Mair, et al. Planta Med. Pharmacokinetics of hERG Channel Blocking Voacangine in Wistar Rats Applying a Validated LC-ESI-MS/MS Method

[5] Yonghyo Kim, et al. Biochem Biophys Res Commun. A natural small molecule voacangine inhibits angiogenesis both in vitro and in vivo

Related TRP Channel Products
SB-705498

SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.
HC-030031

HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50 = 6.2 and 5.3 μM, respectively).
AMG-517

AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
Icilin

Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel.
Phenazopyridine hydrochloride

Phenazopyridine HCl is a competitive SARM1 inhibitor as well as a TRPM8 antagonist with an IC50 for SARM1 inhibition of 145 μM. It has local anesthetic/analgesic activity and can be used in studies related to traumatic brain injury, peripheral neuropathy, and neurodegenerative diseases.
  Catalog
Abmole Inhibitor Catalog




Keywords: Voacangine  supplier, TRP Channel, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.