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Vipivotide tetraxetan

Cat. No. M9750

All AbMole products are for research use only, cannot be used for human consumption.

Vipivotide tetraxetan Structure
Synonym:

PSMA-617

Size Price Availability Quantity
1mg USD 180 In stock
2mg USD 300 In stock
5mg USD 600 In stock
10mg USD 1000 In stock
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Biological Activity

Vipivotide tetraxetan (PSMA-617) is a potent prostate-specific membrane antigen (PSMA) inhibitor with Ki value of 0.37 nM, it is used to make 177Lu-PSMA-617, which is a radioactive molecule to fight cancer. PSMA-617 has a high inhibition potency (equilibrium dissociation constant Ki=2.34±2.94 nM on LNCaP; Ki=0.37±0.21 nM enzymatically determined) and highly efficient internalization into LNCaP cells are demonstrated.

Chemical Information
Molecular Weight 1042.14
Formula C49H71N9O16
CAS Number 1702967-37-0
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hendrik Rathke, et al. J Nucl Med. Response Prediction of 177 Lu-PSMA-617 Radioligand Therapy Using Prostate-Specific Antigen, Chromogranin A, and Lactate Dehydrogenase

[2] Martina Benesova, et al. J Nucl Med. Preclinical Evaluation of a Tailor-Made DOTA-Conjugated PSMA Inhibitor with Optimized Linker Moiety for Imaging and Endoradiotherapy of Prostate Cancer

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Keywords: Vipivotide tetraxetan, PSMA-617 supplier, PSMA, inhibitors, activators

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