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Vicagrel

Cat. No. M14042

All AbMole products are for research use only, cannot be used for human consumption.

Vicagrel Structure

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Quality Control & Documentation
Biological Activity

Vicagrel, an acetate derivative of Clopidogrel, is a P2Y12 platelet inhibitor potentially for the treatment of thrombosis, the substrate of carboxylesterase 2 (CES2). Vicagrel demonstrates a favorable safety profile and excellent anti-platelet activity, which could be an anti-platelet drug and for the unmet medical needs of cardiovascular diseases.

Chemical Information
Molecular Weight 379.86
CAS Number 1314081-53-2
Solubility (25°C) DMSO 150 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hui Li, et al. Platelet inhibitory activity, tolerability, and safety of vicagrel, a novel thienopyridine P2Y12 inhibitor

[2] Yu-Meng Jia, et al. Vicagrel enhances aspirin-induced inhibition of both platelet aggregation and thrombus formation in rodents due to its decreased metabolic inactivation

[3] Jinfang Jiang, et al. Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans

[4] Yuan-Dong Zheng, et al. Pharmacokinetics, mass balance, and metabolism of [ 14 C]vicagrel, a novel irreversible P2Y 12 inhibitor in humans

[5] Yu-Meng Jia, et al. Aspirin Attenuates the Bioactivation of and Platelet Response to Vicagrel in Mice

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Keywords: Vicagrel supplier, inhibitors, activators

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