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Verrucarin J

Cat. No. M30123

All AbMole products are for research use only, cannot be used for human consumption.

Verrucarin J Structure
Synonym:

Muconomycin B

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Quality Control & Documentation
Biological Activity

Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL.

Chemical Information
Molecular Weight 484.54
Formula C27H32O8
CAS Number 4643-58-7
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mange Yu, et al. Appl Microbiol Biotechnol. Two marine natural products, penicillide and verrucarin J, are identified from a chemical genetic screen for neutral lipid accumulation effectors in Phaeodactylum tricornutum

[2] Karen Udoh, et al. Stem Cell Rev Rep. Targeting of Lung Cancer Stem Cell Self-Renewal Pathway by a Small Molecule Verrucarin J

[3] Deeksha Pal, et al. Cell Death Dis. Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer

[4] Kelsey Carter, et al. Oncotarget. Verrucarin J inhibits ovarian cancer and targets cancer stem cells

[5] I A El-Kady, et al. Zentralbl Mikrobiol. Some cultural conditions that control production of verrucarin J, a cytotoxic metabolite of Stachybotrys chartarum

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Keywords: Verrucarin J, Muconomycin B supplier, Apoptosis, inhibitors, activators

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