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Vericiguat is a potent and orally available stimulator of guanylate cyclase (sGC). Vericiguat stimulates the sGC reporter cell line concentration dependently with an EC50 of 1005 ± 145 nM. In the presence of the NO donor S-nitroso-N-acetyl-D,L-penicillamine (SNAP) (30 and 100 nM), the EC50 value shifts to 39.0 ± 5.1 and 10.6 ± 1.7 nM, respectively. Chronic oral treatment with Vericiguat (3 or 10 mg/kg, q.d.) results in a significant attenuation of blood pressure increase during the course of the study. Vericiguat (3 or 10 mg/kg) treatment leads to a significant reduction in kidney injury molecule Kim-1 and osteopontin expression which are used as biomarkers for renal injury and dysfunction.
| Molecular Weight | 426.38 |
| Formula | C19H16F2N8O2 |
| CAS Number | 1350653-20-1 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Guanylate Cyclase Products |
|---|
| Riociguat (BAY 63-2521)
Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the research of ipulmonary hypertension. |
| A 350619 hydrochloride
A 350619 hydrochloride is a soluble guanylyl cyclase (sGC) activator. |
| BAY 41-2272
BAY 41-2272 is a soluble guanylyl cyclase (sGC) activator. |
| BAY 41-8543
BAY 41-8543 is a guanylyl cyclase (sGC) stimulator. |
| Linaclotide
Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. |
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