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Verapamil hydrochloride (VPH) is an orally active L-type calcium channel inhibitor that eliminates calcium channel agonist-induced calcium inward flow and apoptosis. In addition, Verapamil HCl also inhibits voltage-dependent K(+) (Kv) channels, decreasing Kv current amplitude in a concentration-dependent manner, with an apparent K(d) value of 0.82 for inhibition of Kv channels. Verapamil hydrochloride is a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil inhibits CAT1-mediated transport in an uncompetitive manner which is most likely related to its known effect on the membrane potential. Verapamil inhibited CAT1-mediated uptake of l-arginine, l-homoarginine, and ADMA with IC50 values of 85.3, 58.1, and 113 µM, respectively.
| Molecular Weight | 491.06 |
| Formula | C27H38N2O4.HCl |
| CAS Number | 152-11-4 |
| Solubility (25°C) | Water 40 mg/mL DMSO 30 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[3] Syam Krishna, et al. Degradation of Verapamil hydrochloride in water by gliding arc discharge
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