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VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.
| Cell Experiment | |
|---|---|
| Cell lines | Melanoma cells (SKMEL 2, SKMEL 5, SKMEL 28, WM266.4); Colon cancer cells (HCT116, BEneg, BE2, HT29, HT29oxaliR); Ovarian cancer cells (CH1, CH1doxR); Breast cancer cells (MB-231, MB-468, BT20, ZR751, MCF7, BT-474); nontumorigenic cells (HUVEC, MCF10a, PNT |
| Preparation method | Using the sulforhodamine B assay to mearsure antiproliferative effects . Determining HUVEC sensitivity by an alkaline phosphatase method. |
| Concentrations | ~10 μM |
| Incubation time | 4 days |
| Animal Experiment | |
|---|---|
| Animal models | Mice bearing established OVCAR3 human ovarian xenografts |
| Formulation | 10% DMSO, 5% Tween 20, 85% saline |
| Dosages | ~4 mg/kg |
| Administration | i.p. |
| Molecular Weight | 387.82 |
| Formula | C19H18ClN3O4 |
| CAS Number | 940289-57-6 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Xavier Barril, et al. 4-Amino derivatives of the Hsp90 inhibitor CCT018159
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| NVP-HSP990
NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively. NVP-HSP990 has potential antineoplastic activity. |
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