All AbMole products are for research use only, cannot be used for human consumption.
VER-155008 is a potent inhibitor of the HSP70 family, with IC50 of 0.5 μM and 2.6 μM for HSP70 and Grp78, respectively, exhibits >100-fold selectivity over HSP90.
| Cell Experiment | |
|---|---|
| Cell lines | BT474, MB-468, HCT116, and HT29 cells |
| Preparation method | Growing all cell lines in DMEM/10% FCS with GlutaMAX-I in a humidified atmosphere of 5% CO2 in air.Using the sulforhodamine B (SRB) assay to dtermine cell proliferation . |
| Concentrations | 50 μM |
| Incubation time | 72 h |
| Animal Experiment | |
|---|---|
| Animal models | HCT116 tumor bearing |
| Formulation | 10% DMSO/5% Tween 80/85% Saline (v/v/v) |
| Dosages | 40 mg/kg |
| Administration | i.v. |
| Molecular Weight | 556.4 |
| Formula | C25H23Cl2N7O4 |
| CAS Number | 1134156-31-2 |
| Solubility (25°C) | DMSO: 35 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related HSP Products |
|---|
| BIIB021
BIIB021 (CNF2024) is an orally available synthetic non-ansamycin Hsp90 inhibitor with ki value of 1.7nM. |
| CUDC-305
CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class, with IC50 values of 100 and 103 nM for HSP90α and HSP90β, respectively. |
| Ganetespib
Ganetespib (STA-9090) is a potent synthetic small molecule inhibitor of Hsp90 with potential antineoplastic activity. |
| Luminespib (AUY922)
Luminespib (AUY922) is a small molecule Heat Shock Protein 90 (HSP90) inhibitor with IC50 values of 13 and 21 nM for HSP90α and HSP90β respectively. |
| NVP-HSP990
NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively. NVP-HSP990 has potential antineoplastic activity. |
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