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EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione.
| Molecular Weight | 440.66 |
| Formula | C29H44O3 |
| CAS Number | 1213269-98-7 |
| Form | Liquid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Theresa A Zesiewicz, et al. Expert Rev Neurother. Emerging therapies in Friedreich's Ataxia
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