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Varespladib sodium

Cat. No. M28836

All AbMole products are for research use only, cannot be used for human consumption.

Varespladib sodium Structure
Synonym:

LY315920 sodium

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Quality Control & Documentation
Biological Activity

Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.

Chemical Information
Molecular Weight 402.38
Formula C21H19N2NaO5
CAS Number 172733-42-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Rui Wang, et al. Toxicon. Phospholipase A2 inhibitor varespladib prevents wasp sting-induced nephrotoxicity in rats

[2] Yiding Wang, et al. Molecules. Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation

[3] No authors listed. Am J Cardiovasc Drugs. Varespladib

[4] Robert S Rosenson, et al. Expert Opin Investig Drugs. Varespladib methyl in cardiovascular disease

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Keywords: Varespladib sodium, LY315920 sodium supplier, Phospholipase, inhibitors, activators

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