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Valproic acid (VPA) is an HDAC inhibitor with IC50 in the range of 0.5~2 mM, also inhibits HDAC1 with IC50 of 400 μM. Valproic acid (VPA) activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid significantly attenuates the activities of total, cytosol and nuclear HDACs. Valproic acid increases the form of acetylated histone 3 in HeLa cells.
In vivo, Valproic acid (500 mg/kg, i.p.) inhibits the tumor growth and angiogenesisin the mice transplanted with Kasumi-1 cells. The IR rate in the Valproic acid group is 57.25% at the end of the experiment.
| Molecular Weight | 144.21 |
| Formula | C8H16O2 |
| CAS Number | 99-66-1 |
| Form | Liquid (density 0.9 g/mL) |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | Pure form -20°C |
| Related HDAC Products |
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| CUDC-101
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| Givinostat hydrochloride monohydrate
ITF2357 (Givinostat, Gavinostat) is a histone deacetylase inhibitor. The IC50 values for maize HDAC preparations HD2, HD-1B and HD-1A are 10, 7.5 and 16 nM respectively. |
| Niltubacin
Niltubacin, as an inactive derivative of Tubacin, is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6. |
| Tubacin
Tubacin (Tubulin Acetylation Inducer) is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6 with IC50 of 0.004µM. |
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