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Val-cit-PAB-OH is a cathepsin cleavable ADC peptide linker for making MC-Val-Cit-PAB, which is also known as MC-Val-Cit-PAB-OH. MC-Val-Cit-PAB is useful for making ADC (antibody-drug conjugates). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility.
| Molecular Weight | 379.45 |
| Formula | C18H29N5O4 |
| CAS Number | 159857-79-1 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
| Related ADC Linker Products |
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| 6-Maleimidohexanoic acid N-hydroxysuccinimide ester
6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS) is a useful protective group in antibody drug conjugates. |
| Sulfo-NHS
Sulfo-NHS is a peptide condensing agent, can form a stable active ester intermediate, used to prepare hydrophilic active ester, for example as a protein cross-linking agent. N-Hydroxysulfosuccinimide (sodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| SPDP Crosslinker
SPDP crosslinker, or SPDP NHS ester, is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobifunctional protein crosslinker. *The compound is unstable in solutions, freshly prepared is recommended |
| Mc-Val-Cit-PAB
Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). |
| Fmoc-Val-Cit-PAB
Fmoc-Val-Cit-PAB-OH is a cleavable useful heterobifunational linker for making Antibody-Drug-Conjugates (ADC). |
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