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Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT2C) receptor-selective agonist with an EC50 of 8 nM. Vabicaserin exhibits lower affinity at the 5-HT2C antagonist binding site (22 nM) labeled with [3H]mesulergine. Additional binding studies indicate that Vabicaserin possesses affinity for the 5-HT2B and 5-HT1A receptors with Ki values of 14 and 112 nM, respectively.
| Molecular Weight | 264.79 |
| Formula | C15H21ClN2 |
| CAS Number | 887258-94-8 |
| Solubility (25°C) | DMSO 60 mg/mL Water 4 mg/mL |
| Storage | 4°C, dry, sealed |
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