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Ursolic acid (Prunol) is a natural triterpenoid carboxylic acid compound with preventive and anticancer activities. Ursolic acid also has proteasome agonist activity, EC50=14 μmol/L. Ursolic acid efficiently induces apoptosis, possibly via the downregulation of B-cell lymphoma 2 (Bcl-2), the upregulation of Bcl-2-associated X protein and the proteolytic activation of caspase-3. Furthermore, the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase is increased by the administration of ursolic acid. In addition, Ursolic acid significantly suppresses the invasive phenotype of the SNU-484 cells and significantly decreases the expression of matrix metalloproteinase (MMP)-2.
| Molecular Weight | 456.7 |
| Formula | C30H48O3 |
| CAS Number | 77-52-1 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Juhyeon Son, et al. Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid
[3] Sithenkosi Mlala, et al. Ursolic Acid and Its Derivatives as Bioactive Agents
[5] Ran Yin, et al. Ursolic acid, a potential anticancer compound for breast cancer therapy
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