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Uricase

Cat. No. M10640

All AbMole products are for research use only, cannot be used for human consumption.

Uricase Structure
Size Price Availability Quantity
5mg USD 140 In stock
10mg USD 240 In stock
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Quality Control & Documentation
Biological Activity

Uricase is a new type of uric acid-lowering compound, also known as Urate Oxidase, it is characterized by promoting the decomposition of uric acid, catalyzes the rapid oxidation of uric acid into allantoic acid, which is no longer reabsorbed and excreted by the renal tubules, thereby reducing the content of uric acid in the plasma.

Chemical Information
Molecular Weight 567.40
Formula C18H26N5O14P
CAS Number 9002-12-4
Solubility (25°C) Slightly soluble in alkaline buffer
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Nan Fan, et al. PLoS One. Uricase deficiency causes mild and multiple organ injuries in rats

[2] Xiuting Hu, et al. Int J Biol Macromol. Dextrin-uricase conjugate: Preparation, characterization, and enzymatic properties

[3] James T Kratzer, et al. Proc Natl Acad Sci U S A. Evolutionary history and metabolic insights of ancient mammalian uricases

[4] Merry R Sherman, et al. Adv Drug Deliv Rev. PEG-uricase in the management of treatment-resistant gout and hyperuricemia

[5] P A Simkin, et al. N Engl J Med. Monkey uricase

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