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UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity.
| Molecular Weight | 457.84 |
| Formula | C21H23Cl3N2OS |
| CAS Number | 2108826-33-9 |
| Form | Solid |
| Storage | 4°C, dry, sealed |
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