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UNC2881 inhibits Mer kinase activity in 697 B-ALL cells with IC50 of 22 nM, and inhibits collagen-stimulated platelet aggregation.
| Molecular Weight | 463.58 |
| Formula | C25H33N7O2 |
| CAS Number | 1493764-08-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 92 mg/mL Water <1 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related TAM Receptor Products |
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| Bemcentinib
Bemcentinib (R428) is a potent and selective small-molecule inhibitor of Axl kinase with IC50 of 14 nM. |
| SGI-7079
SGI-7079 is a novel Axl inhibitor. |
| UNC2250
UNC2250 is a potent and selective Mer inhibitor with IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3. |
| Dubermatinib
Dubermatinib (TP-0903) is a potent and selective AXL inhibitor with an IC50 value of 27 nM. |
| RU-301
RU-301 is a pan-TAM receptor inhibitor that blocks Gas6-induced TAM activation and tumorigenicity, with Kd and IC50 values of 12 μM and 10 μM, respectively. |
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