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UNC1215 is a potent and selective MBT (malignant brain tumor) antagonist, which binds L3MBTL3 with IC50 of 40 nM and Kd of 120 nM, 50-fold selective versus other members of the human MBT family.
| Cell Experiment | |
|---|---|
| Cell lines | HEK293T/17 cells |
| Preparation method | CellTiter-Glo luminescent cell viability assay |
| Concentrations | ~100 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 529.72 |
| Formula | C32H43N5O2 |
| CAS Number | 1415800-43-9 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Qianqian Wang, et al. PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes
[3] Narkhyun Bae, et al. Developing Spindlin1 small-molecule inhibitors by using protein microarrays
[4] Brandi M Baughman, et al. The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer
[5] Lindsey I James, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
| Related Epigenetic Reader Domain Products |
|---|
| RVX-208
Apabetalone (RVX-208) is a first-in-class, small molecule inhibitor of BET bromodomain with IC50 of 0.51 μM for BD2. |
| I-BET151
I-BET151 (GSK1210151A) is an inhibitor of the BET family with IC50 of 0.5 μM, 0.25 μM and 0.79 μM for BRD2, BRD3 and BRD4, respectively. |
| (+)-JQ1
(+)-JQ1 is a BET bromodomain inhibitor that acts on BRD4(2) with an IC50 of 33 nM and binds to all bromodomain domains in the BET family, but not to bromodomain domains outside the BET family. JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway, and JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway. |
| I-BET-762
I-BET-762 (GSK525762) is a selective small molecule BET inhibitor. |
| CPI-0610
CPI-0610 is a novel BET protein bromodomain inhibitor. |
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