Free shipping on all orders over $ 500

Umibecestat

Cat. No. M28304

All AbMole products are for research use only, cannot be used for human consumption.

Umibecestat Structure
Synonym:

CNP520

Size Price Availability Quantity
1mg USD 210 In stock
5mg USD 450 In stock
10mg USD 650 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease.

Chemical Information
Molecular Weight 513.8
Formula C19H15ClF7N5O2
CAS Number 1387560-01-1
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage 4°C, protect from light
References

[1] Rainer Machauer, et al. J Med Chem. Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease

[2] Alvaro Miranda, et al. J Alzheimers Dis. Selective Secretase Targeting for Alzheimer's Disease Therapy

[3] Ulf Neumann, et al. EMBO Mol Med. The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease

Related Gamma-secretase/Beta-secretase Products
DAPT

DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. DAPT inhibits the activation of Notch 1 signaling.

BMS-708163

BMS-708163 (Avagacestat) is a selective γ-secretase inhibitor (IC50 = 0.3 nM).

RO4929097

RO4929097 is a potent and selective inhibitor of γ-secretase and as a result is able to inhibit Notch pathway signaling.

MK-0752

MK-0752 is a potent, oral inhibitor of γ-secretase with IC50 of 5 nM in human SH-SY5Y cells.

LY-411575

LY-411575 is potent and selective small molecule γ-secretase inhibitor with IC50 of 0.1 nM for APP23 and APP51/16 primary neurons.

  Catalog
Abmole Inhibitor Catalog




Keywords: Umibecestat, CNP520 supplier, Gamma-secretase/Beta-secretase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.