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UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.
| Molecular Weight | 466.05 |
| Formula | C29H35NO2HCl |
| CAS Number | 136647-02-4 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | -20°C, dry, sealed |
[1] No authors listed. Anagrelide
[2] No authors listed. Carteolol
[3] No authors listed. Atovaquone and Proguanil
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